SL 220B 723 W. Michigan St. Indianapolis, IN 46202
Education
B.S. Aerospace Engineering, Georgia Institute of Technology, 2002
M.S. Biomedical Engineering, The University of Michigan, 2004
Ph.D. Biomedical Engineering, The University of Michigan, 2007
Professional Experience
Postdoctoral Fellow, The University of Michigan, Department of Chemistry and Michigan Nanotechnology Institute for Medicine and Biological Sciences, 10/2007 - 9/2010
Graduate Research Assistant, The University of Michigan, Biomimetics and Biomechanics of Hard Tissues Laboratory, Department of Biomedical Engineering, 5/2002 - 10/2007
Awards & Honors
The lab was awarded a 5 year, nearly $2M grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)! The grant is titled "Targeting collagen as an interventional approach to improve bone material properties." This work is focused on combination treatments which impact bone quantity and quality for a number of relevant diseases which have musculoskeletal complications., 7/2018
IUPUI Trustees’ Teaching Award, 3/2018
Selected Publications
Hammond MA, Wallace JM, Allen MR, Siegmund T, "Incorporating Anisotropy and Heterogeneity in Finite Element Models of Trabecular Bone Altered Predicted Stress," Biomechanics and Modeling in Mechanobiology, 2018; 17(2): 605-614., 10/2018
Hongji Z, Harbin S, Brookes SE, Wallace JM, Halum S, "Use of autologous adipose-derived mesenchymal stem cells for creation of laryngeal cartilage," The Laryngoscope, 2018; 128: E123-E129., 10/2018
Allen MR, McNerny EMB, Aref MW, Organ JM, Newman CL, McGowan B, Jaing T, Burr DB, Brown DM, Hammond MA, Territo PR, Lin C, Persohn S, Jiang L, Riley AA, McCarthy BP, Hutchins GD, Wallace JM, "Effects of combination treatment with Alendronate and Raloxifene on skeletal properties in a beagle dog model," PloS One, 2017; 12(8): e0181750., 10/2018
Stringer M, Abeysekera I, Thomas J, LaCombe J, Stancombe K, Stewart R, Dria K, Wallace JM, Goodlet C, Roper R, "Epigallocatechin-3-gallate (EGCG) consumption in the Ts65Dn model of down syndrome fails to improve behavioral deficits and is detrimental to skeletal phenotypes," Physiology and Behavior, 2017; 177: 230-241., 10/2018
Larsen R, Peveler J, Klutke J, Hickman D, Aref MW, Wallace JM, Brown D, Allen MR, "Effects of daily restraint with and without injections on skeletal properties in C57BL/6NHsd mice," Lab Animal, 2017; 46(7): 299-301., 10/2018
Meixner CN, Aref MW, Gupta A, McNerny EMB, Brown D, Wallace JM, Allen MR, "Raloxifene improves bone mechanical properties in mice previously treated with zoledronate," Calcified Tissue International, 2017; 101(1): 75-81., 10/2018
TruongVo T, Kennedy RM, Chen H, Chen A, Berndt A, Agarwal M, Zhu L, Naksharti H, Wallace JM, Na S, Yokota H, Ryu JE, "Microfluidic Channel for Characterizing Normal and Breast Cancer Cells," Journal of Micromechanics and Microengineering, 2017; 29; 035019., 10/2018
Pacheco-Costa R, Kadakia JR, Wallace JM, Plotkin LI, Reginato RD, "Connexin37 deficiency alters organic bone matrix, cortical bone geometry, and increases Wnt/β-catenin signaling," BONE, 2017; 97:105-113., 10/2018
Vesper EO, Hammond MA, Allen MR, Wallace JM, "Even With Rehydration, Preservation in Ethanol Influences the Mechanical Properties of Bone and How Bone Responds to Experimental Manipulation," BONE, 2017; 97:49-53., 10/2018
Sugatani T, Agapova OA, Fang Y, Berman AG, Wallace JM, Malluche H, Smith W, Sung V, Hruska KA, "Ligand trap of the activin receptor type IIA inhibits osteoclast stimulation of bone remodeling in diabetic mice with chronic kidney disease," Kidney International, 2017; 91(1): 11-13., 10/2018
Allen MR, Aref MW, Newman CL, Kadakia JR, Wallace, JW, "Raloxifene neutralizes bone brittleness induced by anti-remodeling treatment and increases fatigue life through non-cell mediated mechanisms," Actualizaciones en Osteologia, 2016; 12(3): 163-173., 10/2018
Takigawa H, Frondorf B, Liu S, Liu Y, Li B, Sudo A, Wallace JM, Yokota H, Hamamura K, "Salubrinal improves mechanical properties of the femur in osteogenesis imperfecta Mice," Journal of Pharmacological Sciences, 2016; 132(2):154-161., 10/2018
Canelon S, Wallace JM, "β-aminopropionitrile-induced reduction in enzymatic crosslinking causes in vitro changes in collagen morphology and molecular composition," PloS One, 2016; 11(11): e0166392., 10/2018
Hammond MA, Berman AG, Laine TJ, Wallace JM, "Treadmill Exercise Improves Fracture Toughness and Indentation Modulus Without Altering the Nanoscale Morphology of Collagen in Mice," PloS One, 2016; 11(9): e0163273., 10/2018
McNerny EMB, Organ JM, Wallace JM, Newman CL, Brown DM, Allen MR, "Assessing the inter- and intra-animal variability of in vivo OsteoProbe skeletal measures in untreated dogs,", Bone Reports, 2016; 5: 192-198., 10/2018
Hammond MA, Berman AG, Pacheco R, Davis HM, Plotkin LI, Wallace JM, "Removing or truncating connexin 43 in murine osteocytes alters cortical geometry, nanoscale morphology, and tissue mechanics in the tibia," Bone, 2016; 88: 85-91., 10/2018
Krege B, Aref M, McNerny E, Wallace JM, Organ JM, Allen MR, "Reference point indentation is insufficient for detecting alterations in traditional mechanical properties of bone under common experimental conditions," Bone, 2016; 87: 97-101., 10/2018
Blum KM, Novak T, Neu CP, Wallace JM, Bart ZR, Voytik-Harbin SL, "Acellular and Cellular High-Density, Collagen-Fibril Constructs with Suprafibrillar Organization," Biomaterials Science, 2016; 4: 711-723., 10/2018
Newman CL, Tian N, Hammond MA, Wallace JM, Brown DM, Chen NX, Moe SM, Allen MR, "Calcitriol Suppression of Parathyroid Hormone Fails to Improve Skeletal Properties in an Animal Model of Chronic Kidney Disease," American Journal of Nephrology, 2016; 43(1): 20-31., 10/2018
Berman AG, Wallace JM, Bart ZB, Allen MR, "Raloxifene reduces skeletal fractures in an animal model of osteogenesis imperfecta", Matrix Biology, 2016; 52-54: 19-28., 10/2018
Expertise
Mechanical Properties of Biological Tissues, Mechanically-mediated skeletal adaptation, Atomic Force Microscopy
Interests
Role collagen plays in bone health and fracture resistance; Mechanically-mediated skeletal adaptation; Combinatorial drug and mechanical therapeutics for defects and disease in bone; Hierarchical structure/function relationships in cells, tissues and organs
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