Education

  • BS, MS, and PhD in Astronautics, University of Tokyo, Japan, 1978, 1980, and 1983
  • PhD in Molecular, Cellular, and Developmental Biology, Indiana University Bloomington, 1993
  • Postdoctoral Fellow, Molecular Biotechnology, University of Washington School of Medicine, 1993-1998

Professional Experience

  • Research Assistant Professor, Institute of Space and Astronautical Science, Japan,1983-1988
  • Assistant Professor, Mechanical Engineering, IUPUI, Anatomy and Cell Biology, IU School of Medicine, 1998-2004
  • Associate Professor, Biomedical Engineering and Mechanical Engineering, IUPUI; Anatomy and Cell Biology, IU School of Medicine 2004-2008
  • Professor, Biomedical Engineering and Mechanical Engineering, IUPUI; Anatomy Cell Biology and Physiology, IU School of Medicine 2008-present

Awards and Honors

  • Fulbright Scholarship, Aeronautics and Astronautics, Stanford University, 1980-1981
  • Fellow, American Institute for Medical and Biological Engineering, 2009

Selected Publications

  • Fan Y, Zha R, Sano T, Zhao X, Liu S, Woollam MD, Wu D, Sun X, Li K, Egi M, Li F, Minami K, Siegel A, Horiuchi T, Liu J, Agarwal M, Sudo A, Nakshatri H, Li B, Yokota H. (2021). Mechanical tibia loading remotely suppresses breast cancer-associated brain tumors by the dopamine-mediated downregulation of CCN4. Bone Research (in press).
  • Feng Y, Liu S, Zha R, Sun X, Li K, Robling A, Li BY, Yokota H (2021). Mechanical loading-driven tumor suppression is mediated by Lrp5-dependent and independent mechanisms. Cancers (Basel) 13:267.
  • Fan Y, Jalali A, Chen A, Zhao X, Liu S, Teli M, Guo Y, Li F, Li J, Siegel A, Yang L, Liu J, Na S, Agarwal M, Robling AG, Nakshatri H, Li BY, Yokota H (2020). Skeletal loading regulates breast cancer-associated osteolysis in a loading intensity-dependent fashion. Bone Research 8:9. 
  • Liu S, Wu D, Sun X, Fan Y, Zha R, Jalali A, Teli M, Sana T, Siegel A, Sudo A, Agarwal M, Robling A, Li BY, Yokota H (2020). Mechanical stimulations can inhibit local and remote tumor progression by downregulating WISP1. FASEB J34:12847-12859.
  • Wu D, Fan Y, Liu S, Woollam MD, Sun X, Murao E, Zha R, Prakash R, Park C, Siegel AP, Liu J, Agarwal M, Li BY, Yokota H (2020). Loading-induced anti-tumor capability of murine and human urine. FASEB J 34:7578-7592.

Expertise

control theory/bioinformatics, mechanics, cancer/bone biology

Interests

breast/prostate cancer, bone/brain metastases, osteoporosis, arthritis