Advanced Biomolecular Engineering
BME 69500/ 3 Cr.
One of the most challenging tasks for the current biomedical engineers is to extract biologically important information from a large amount of data such as genomic DNA sequences and mRNA/protein expression data. Using examples in human genomics and proteomics, this course describes cutting-edge biomolecular technologies, computational algorithms, and mathematical models. The first half is genomics focusing on experimental designs with microarrays and analyses of microarray-derived data, and the second half is proteomics focusing on the principles of mass spectrometry and analyses of protein expression data. The subjects include structure of human genome, DNA microarrays, cluster analyses, singular value decomposition, modeling and voting, mass spectroscopy, protein arrays, systems biology, and biostatistics.
- Available Online: No
- Credit by Exam: No
- Laptop Required: No
P: Students should be able to use matrices (linear algebra) and some software programming tools (e.g., Matlab, C, Visual Basic, etc.). Prior knowledge of structure and function of DNA and proteins, and gene regulation is highly recommended. Consultation with the instructor is encouraged.
There are no required textbooks. Handouts and journal articles are made available to the students.