Implantable Materials and Biological Response
BME 38100/ 3 Cr.
This course combines biomaterials, their biological response, and interactions between implantable materials and biological systems. Materials science of implantable materials; overview of implantable biomaterials and interactions between implants and biosystems; in vitro and in vivo biocompatibility tests; and specific examples on implant-tissue interactions, biocompatibility, and evaluation tools are presented.
- Available Online: No
- Credit by Exam: No
- Laptop Required: No
P: BIOL-K 101 and CHEM-C 106.
- Biomaterials: The Intersection of Biology and Materials Science (1st Edition, Pearson), by Temenoff and Mikos (ISBN-13: 978-0-13-009710-1).
- Janeway’s Immunobiology (8th Edition, Garland Science), by Kenneth Murphy (ISBN 978-0-8153-4243-4) (italicized chapter numbers).
To help students know implantable biomaterials and better understand interactions between the implants and biosystem.
Upon completion of the course, students will be able to:
- Know basic implantable biomaterials 
- Understand interactions between implantable biomaterials and tissues 
- Know how to select and use basic in vitro and vivo biocompatibility tests to evaluate the tissue response to the implantable biomaterials 
- Know how to characterize the interfaces between the implant and biosystems. 
- Overview of basic materials science
- Chemical structures and physical properties of implantable materials
- Biological materials
- Tissue response to implants
- Blood and clotting
- Immunological response
- Innate immunity
- Adaptive immunity
- Degradation of implantable materials
- Surface properties of implantable materials
- Protein-material interactions
- Cell-material interactions
- Implantable materials processing, characterizations, and sterilization
- Biocompatibility & Tissue engineering
- Tumorigenesis, transplantation and tolerance
- Wound healing
- Manipulation of the immune response