Implantable Materials and Biological Response

BME 38100/ 3 Cr.

This course combines biomaterials, their biological response, and interactions between implantable materials and biological systems. Materials science of implantable materials; overview of implantable biomaterials and interactions between implants and biosystems; in vitro and in vivo biocompatibility tests; and specific examples on implant-tissue interactions, biocompatibility, and evaluation tools are presented.

• Available Online: No
• Credit by Exam: No
• Laptop Required: No

Prerequisites/Co-requisites:

P: BIOL-K 101 and CHEM-C 106.

Textbooks

• Biomaterials: The Intersection of Biology and Materials Science (1st Edition, Pearson), by Temenoff and Mikos (ISBN-13: 978-0-13-009710-1).
• Janeway’s Immunobiology (8th Edition, Garland Science), by Kenneth Murphy (ISBN 978-0-8153-4243-4) (italicized chapter numbers).

Instruction Goal

To help students know implantable biomaterials and better understand interactions between the implants and biosystem.

Outcomes

Upon completion of the course, students will be able to:

• Know basic implantable biomaterials [1]
• Understand interactions between implantable biomaterials and tissues [1]
• Know how to select and use basic in vitro and vivo biocompatibility tests to evaluate the tissue response to the implantable biomaterials [1]
• Know how to characterize the interfaces between the implant and biosystems. [1]

Topics

• Overview of basic materials science
• Chemical structures and physical properties of implantable materials
  • Metals/Ceramics/Polymers/Composites
  • Biological materials
• Tissue response to implants
• Blood and clotting
• Immunological response
  • Innate immunity
  • Adaptive immunity
• Degradation of implantable materials
• Surface properties of implantable materials
  • Protein-material interactions
  • Cell-material interactions
• Implantable materials processing, characterizations, and sterilization
• Biocompatibility & Tissue engineering
• Hypersensitivity
• Tumorigenesis, transplantation and tolerance
• Biofilms
• Wound healing
• Manipulation of the immune response